Hay W M, Nathan P E, Heermans H W, Frankenstein W
Addict Behav. 1984;9(1):67-77. doi: 10.1016/0306-4603(84)90008-x.
Relationships between variations in blood alcohol level (BAL) and blood alcohol level discrimination accuracy were investigated as a function of menstrual cycle, hormonal variations, and behavioral tolerance to alcohol in 20 female social drinkers. All subjects consumed a moderate dose of alcohol on three occasions during one complete menstrual cycle. Subjects estimated their level of intoxication eight times during each drinking session. Each subject's behavioral tolerance to alcohol each session was assessed by a body sway procedure. Subjects also completed detailed questionnaires on symptoms related to menstrual period and familial history of alcohol use. Contrary to earlier reports, (1) no difference in total time of intoxication or in other indices of ethanol metabolism was found between women (N = 9) who were not taking birth control pills and those (N = 11) who were and (2) no difference was found in peak BAL as a function of menstrual cycle phase. Stage of menstrual cycle did not affect the accuracy of BAL estimation. A trend approaching significance suggested that, with increasing BAL, women in the oral contraceptive group were more accurate in their estimates of intoxication. A significant interaction between menstrual cycle phase and tolerance levels was found; high tolerant women were significantly less accurate than low tolerant women in estimating BAL during the midcycle phase of the menstrual cycle.
在20名女性社交饮酒者中，研究了血液酒精浓度（BAL）变化与血液酒精浓度辨别准确性之间的关系，该关系是月经周期、激素变化和酒精行为耐受性的函数。所有受试者在一个完整的月经周期内分三次饮用适量的酒精。受试者在每次饮酒过程中估计自己的醉酒程度八次。每次饮酒过程中，通过身体摇摆程序评估每个受试者对酒精的行为耐受性。受试者还填写了有关月经相关症状和饮酒家族史的详细问卷。与早期报告相反，（1）未服用避孕药的女性（N = 9）和服用避孕药的女性（N = 11）在醉酒总时长或乙醇代谢的其他指标上没有差异，（2）血液酒精浓度峰值在月经周期各阶段也没有差异。月经周期阶段不影响血液酒精浓度估计的准确性。一种接近显著的趋势表明，随着血液酒精浓度升高，口服避孕药组的女性对醉酒程度的估计更准确。发现月经周期阶段与耐受性水平之间存在显著交互作用；在月经周期的中期阶段，高耐受性女性在估计血液酒精浓度时比低耐受性女性的准确性显著更低。
