Cole-Harding S, Wilson J R
J Stud Alcohol. 1987 Jul;48(4):380-7. doi: 10.15288/jsa.1987.48.380.
Data from the Colorado Alcohol Research on Twins and Adoptees project were analyzed to determine whether 63 women and 75 men differ on three measures of ethanol pharmacokinetics: absorption rate, peak blood alcohol level and elimination rate. The data on women were analyzed separately to investigate whether female hormones influenced the measures of ethanol metabolism by comparing groups tested at different phases of the menstrual cycle and a group who were taking oral contraceptives. Subjects were given 0.80 g of alcohol per kg of body weight diluted by 7 parts of carbonated water or a sugar- and caffeine-free soft drink. This dose was calculated to bring their blood alcohol level (BAL) to near 100 mg/dl. Additional doses were given at the end of each of the next 2 hr in an attempt to maintain BAL near peak for approximately 3 hr. An analysis of beta 60 values showed that women metabolized ethanol faster than men, regardless of phase of menstrual cycle or whether they were taking birth control pills. There was a small gender difference in peak BAL and no gender difference in time to peak BAL. It was also found that the peak BAL attained by subjects had a substantial effect on the beta 60. The effects of smoking, age, ponderal index and reported drinking habits on ethanol metabolism were also analyzed.
对科罗拉多双胞胎与领养者酒精研究项目的数据进行了分析，以确定63名女性和75名男性在乙醇药代动力学的三个指标上是否存在差异：吸收率、血液酒精峰值水平和消除率。对女性数据进行了单独分析，通过比较在月经周期不同阶段测试的组和服用口服避孕药的组，来研究女性激素是否会影响乙醇代谢指标。给受试者每公斤体重服用0.80克酒精，用7份碳酸水或无糖无咖啡因软饮料稀释。计算该剂量以使他们的血液酒精水平（BAL）接近100毫克/分升。在接下来的2小时结束时给予额外剂量，试图使BAL在大约3小时内接近峰值。对β60值的分析表明，无论月经周期处于哪个阶段或是否服用避孕药，女性代谢乙醇的速度都比男性快。血液酒精峰值水平存在微小的性别差异，达到血液酒精峰值的时间没有性别差异。还发现受试者达到的血液酒精峰值水平对β60有很大影响。还分析了吸烟、年龄、体重指数和报告的饮酒习惯对乙醇代谢的影响。
