Rose J E, Zinser M C, Tashkin D P, Newcomb R, Ertle A
Addict Behav. 1984;9(2):211-5. doi: 10.1016/0306-4603(84)90060-1.
Subjective response to cigarette smoking was assessed after partial blockade of upper and lower airway sensations by the topical application of lidocaine. Pack-a-day smokers were given one cigarette after each of four conditions: (1) mouth anesthesia, obtained by rinsing the mouth with 2% lidocaine; (2) mouth and pharyngeal anesthesia, in which subjects rinsed their mouths and gargled with 2% lidocaine; (3) upper and lower airway anesthesia, in which subjects rinsed their mouths and gargled with a 2% lidocaine solution, and inhaled a mist containing 4% lidocaine (60 breaths); and (4) saline control, in which all solutions (rinse, gargle and inhalation) were saline. A significant linear decline in cigarette craving occurred with increasing anesthesia, and desirability ratings over the first several puffs were also reduced by anesthesia. These results suggest that sensory cues are important factors in smoking satisfaction, and their influence can be analyzed with the use of local anesthetics.
在通过局部应用利多卡因部分阻断上、下气道感觉后，评估了对吸烟的主观反应。每天吸一包烟的吸烟者在以下四种情况下每次吸一支烟：（1）口腔麻醉，通过用2%利多卡因漱口获得；（2）口腔和咽部麻醉，受试者用2%利多卡因漱口和漱口；（3）上、下气道麻醉，受试者用2%利多卡因溶液漱口和漱口，并吸入含有4%利多卡因的雾气（60次呼吸）；（4）生理盐水对照，所有溶液（冲洗、漱口和吸入）均为生理盐水。随着麻醉程度的增加，对香烟的渴望显著呈线性下降，麻醉也降低了最初几口的满意度评分。这些结果表明，感觉线索是吸烟满意度的重要因素，并且可以使用局部麻醉剂来分析它们的影响。
