Bertram T A, Jensen A E
Am J Vet Res. 1984 Jun;45(6):1099-104.
Morphology and function of equine neutrophils were evaluated after combination with contagious equine metritis organism (CEMO) or 1 of 2 CEMO lipopolysaccharides (LPS). The 2 LPS (LPS-a; LPS-p) isolated from the CEMO contained 14- and 16-carbon fatty acids, ketodeoxyoctanate, hexose, and heptose, but were morphologically distinct. Neutrophils exposed to LPS had fewer granules, whereas those exposed to CEMO had more granules than did the controls (phosphate-buffered saline solution). Neutrophil iodination was significantly increased with 10 and 25 micrograms of LPS-a, but not significantly altered by LPS-p or CEMO. Staphylococcus aureus ingestion was not influenced by CEMO and was mildly decreased by LPS-a. These results indicate that CEMO may have at least 2 functionally and morphologically distinct, but chemically similar, LPS and that 1 of these LPS (LPS-a) may enhance neutrophil killing by stimulating neutrophil iodinating mechanisms.
将马中性粒细胞与马传染性子宫炎病原体（CEMO）或两种CEMO脂多糖（LPS）之一结合后，对其形态和功能进行了评估。从CEMO分离出的两种LPS（LPS-a；LPS-p）含有14碳和16碳脂肪酸、酮脱氧辛酸、己糖和庚糖，但形态不同。暴露于LPS的中性粒细胞颗粒较少，而暴露于CEMO的中性粒细胞颗粒比对照组（磷酸盐缓冲盐水溶液）更多。10微克和25微克的LPS-a可使中性粒细胞碘化显著增加，但LPS-p或CEMO未使其发生显著改变。金黄色葡萄球菌的摄取不受CEMO影响，而LPS-a使其略有减少。这些结果表明，CEMO可能至少有两种功能和形态不同但化学性质相似的LPS，其中一种LPS（LPS-a）可能通过刺激中性粒细胞碘化机制来增强中性粒细胞的杀伤作用。
