Fernie D S, Batty I, Walker P D, Platt H, Mackintosh M E, Simpson D J
Res Vet Sci. 1980 May;28(3):362-7.
The vaccination of four ponies on two occasions with a formolised culture of Haemophilus equigenitalis produced a high circulating antibody titre to the organism in each pony. Three out of four vaccinated and all of three unvaccinated ponies developed typical symptoms of contagious equine metritis (CEM) when subsequently challenged with a vaginal exudate containing H equigenitalis. Similarly, three ponies which had previously been infected with H equigenitalis and which had recovered spontaneously also developed contagious equine metritis when rechallenged with the organism. The clinical and bacteriological symptoms in the vaccinated ponies and in the rechallenged ponies were less severe than those observed in the unvaccinated ponies but H equigenitalis was still recovered 17 days after challenge from the three vaccinated ponies which had developed CEM. The vaccinated pony which remained free from infection did not exhibit the highest circulating antibody titre of the vaccinates before challenge.
用甲醛处理的马生殖嗜血杆菌培养物对4匹小马进行两次接种后，每匹小马体内针对该菌产生了高循环抗体滴度。在随后用含有马生殖嗜血杆菌的阴道分泌物进行攻毒时，4匹接种疫苗的小马中有3匹以及所有3匹未接种疫苗的小马都出现了传染性马子宫内膜炎（CEM）的典型症状。同样，3匹先前感染过马生殖嗜血杆菌且已自发康复的小马在再次受到该菌攻毒时也出现了传染性马子宫内膜炎。接种疫苗的小马和再次攻毒的小马的临床和细菌学症状比未接种疫苗的小马观察到的症状要轻，但在攻毒17天后，从出现CEM的3匹接种疫苗的小马中仍分离到了马生殖嗜血杆菌。未感染的接种疫苗的小马在攻毒前并未表现出接种疫苗的小马中最高的循环抗体滴度。
