慢性地高辛治疗期间的洋地黄“受体”
Digitalis 'receptors' during chronic digoxin treatment.
作者信息
Malini P L, Strocchi E, Marata A M, Ambrosioni E
出版信息
Clin Exp Pharmacol Physiol. 1984 May-Jun;11(3):285-90. doi: 10.1111/j.1440-1681.1984.tb00266.x.
The effect of digoxin treatment on Mg-dependent [Na+-K+]-ATPase (the receptor for cardiac glycosides) was assessed by comparison of intracellular Na+-K+, 86Rb uptake and number of digoxin binding sites in the erythrocytes of 138 patients on long term digoxin and of 133 control subjects. The parameters were also assessed in thirty-two patients followed longitudinally for 1 y. The results indicate that the cells adapt to chronic exposure to 'therapeutic' dosage of digoxin with an overcompensatory synthesis of new receptors, a possible mechanism through which the normal intraerythrocytic ionic equilibrium is re-established. The process of synthesis of new receptors appears to be completed in erythrocytes in a period of 4 months after the start of digoxin treatment.
通过比较138例长期服用地高辛患者和133例对照者红细胞内的Na⁺-K⁺、⁸⁶Rb摄取以及地高辛结合位点数量，评估地高辛治疗对镁依赖性[Na⁺-K⁺]-ATP酶（强心苷受体）的影响。还对32例患者进行了为期1年的纵向随访并评估这些参数。结果表明，细胞会适应长期暴露于“治疗性”剂量的地高辛，通过新受体的过度代偿性合成来重新建立正常的红细胞内离子平衡，这可能是一种机制。新受体的合成过程似乎在开始地高辛治疗后的4个月内在红细胞中完成。
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