在洋地黄毒苷治疗早期，患者红细胞中强心苷受体位点、86铷摄取及细胞内钠浓度出现的急性变化，在慢性治疗期间并未出现：对慢性洋地黄毒苷治疗的药理学及治疗学意义。
The acute changes seen in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients during the early phases of digoxin therapy are not found during chronic therapy: pharmacological and therapeutic implications for chronic digoxin therapy.
作者信息
Ford A R, Aronson J K, Grahame-Smith D G, Carver J G
出版信息
Br J Clin Pharmacol. 1979 Aug;8(2):135-42. doi: 10.1111/j.1365-2125.1979.tb05811.x.
Abstract
1 Measurements of the binding of 12-alpha-[3H]-digoxin to the membranes of intact erythrocytes, erythrocyte 86rubidium uptake and intraerythrocytic sodium concentrations have been made in the red cells of various groups of patients--those who have not received digoxin, those during the early phases of treatment, those during chronic (greater than 2 months) treatment, and those toxic. 2 The values of those measurements in the patients in the early phases of therapy and in the toxic patients differed significantly from those of the untreated patients. 3 However, the values in the chronically treated patients were not different from those of the untreated patients. 4 The results suggest that the biochemical pharmacological effects of digoxin which occur during the early phases of therapy do not persist in the long-term. 5 The possible clinical significance of these observations is discussed.
摘要
- 已对各类患者的红细胞进行了以下测量：12-α-[3H]-地高辛与完整红细胞膜的结合、红细胞对86铷的摄取以及红细胞内钠浓度，这些患者包括未接受地高辛治疗的患者、治疗早期的患者、慢性（超过2个月）治疗的患者以及中毒患者。2. 治疗早期患者和中毒患者的这些测量值与未治疗患者的测量值有显著差异。3. 然而，长期治疗患者的测量值与未治疗患者的测量值并无差异。4. 结果表明，治疗早期出现的地高辛生化药理作用不会长期持续。5. 讨论了这些观察结果可能的临床意义。
相似文献
1
The acute changes seen in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients during the early phases of digoxin therapy are not found during chronic therapy: pharmacological and therapeutic implications for chronic digoxin therapy.在洋地黄毒苷治疗早期，患者红细胞中强心苷受体位点、86铷摄取及细胞内钠浓度出现的急性变化，在慢性治疗期间并未出现：对慢性洋地黄毒苷治疗的药理学及治疗学意义。
Br J Clin Pharmacol. 1979 Aug;8(2):135-42. doi: 10.1111/j.1365-2125.1979.tb05811.x.
2
Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation.在心力衰竭伴正常节律及心房颤动患者接受地高辛治疗的早期阶段，其红细胞中强心苷受体位点、铷⁸⁶摄取及细胞内钠浓度的变化。
Br J Clin Pharmacol. 1979 Aug;8(2):125-34. doi: 10.1111/j.1365-2125.1979.tb05810.x.
3
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Regeneration of cation-transport capacity in HeLa cell membranes after specific blockade by ouabain.哇巴因特异性阻断后HeLa细胞膜阳离子转运能力的再生
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