Scarpelli P T, Fersini C, Sensi G, Corti C, Croppi E, Romano S, Tarquini B
Chronobiologia. 1984 Apr-Jun;11(2):141-5.
No mention is made of any aspect of BP bioperiodicity, among current clinical criteria for diagnosing pregnancy-related hypertension. The abnormal BP, based on a single unqualified measurement, is accepted and utilized as a clinical feature to identify pregnancy at risk. Systolic, diastolic and mean arterial blood pressure were measured every 15 min for 24 h in 5 women (2 non pregnant clinically healthy subjects, 1 clinically healthy subject in her third trimester of pregnancy, 1 presenting mild and 1 severe toxiemia, also in their third trimester of pregnancy) by an automated BP recording apparatus (Dynamap). All variables, analyzed by the single cosinor method, exhibited statistically significant circadian rhythms. A high amplitude could nullify the time-unqualified usual range. The change in circadian amplitude precedes an overt mesor hypertension and constitutes a tool for earlier detection of fetal distress.
在当前诊断妊娠相关高血压的临床标准中，未提及血压生物周期性的任何方面。基于单次不合格测量得出的异常血压被接受并用作识别有风险妊娠的临床特征。使用自动血压记录装置（Dinamap），对5名女性（2名临床健康的非孕妇、1名妊娠晚期临床健康的孕妇、1名妊娠晚期出现轻度毒血症的孕妇和1名妊娠晚期出现重度毒血症的孕妇）每15分钟测量一次收缩压、舒张压和平均动脉压，持续24小时。通过单余弦法分析的所有变量均显示出具有统计学意义的昼夜节律。高振幅可能会使通常的非定时范围无效。昼夜振幅的变化先于明显的平均血压升高，是早期检测胎儿窘迫的一种手段。
