Sonnenfeld G, Hudgens R W, Streips U N
Environ Res. 1984 Aug;34(2):280-6. doi: 10.1016/0013-9351(84)90096-3.
The effects of several aromatic carcinogens and their noncarcinogenic analogs on the production of alpha/beta interferon by mouse embryo fibroblasts were determined. The carcinogens 2-naphthylamine and 9,10-dimethylanthracene significantly depressed alpha/beta interferon production, while their poorly or noncarcinogenic analogs, 1-naphthylamine and anthracene, respectively, had no significant effect. Neither the carcinogen benzidine nor its poorly carcinogenic analog 3,3',5,5'-tetramethylbenzidine had any effect on alpha/beta interferon production. These data, taken together with previous findings, suggest the possibility of drawing a high correlation between the carcinogenic potential of a chemical and its effect on interferon production.
测定了几种芳香族致癌物及其非致癌类似物对小鼠胚胎成纤维细胞产生α/β干扰素的影响。致癌物2-萘胺和9,10-二甲基蒽显著抑制α/β干扰素的产生，而它们的弱致癌或非致癌类似物1-萘胺和蒽分别没有显著影响。致癌物联苯胺及其弱致癌类似物3,3',5,5'-四甲基联苯胺对α/β干扰素的产生均无影响。这些数据与先前的研究结果一起表明，有可能在化学物质的致癌潜力与其对干扰素产生的影响之间建立高度相关性。
