Michel G, Mosser J, Olle J
Eur J Drug Metab Pharmacokinet. 1984 Apr-Jun;9(2):149-53. doi: 10.1007/BF03189618.
Two doxycycline derivatives Doxycycline polyphosphate and Doxycycline hydrochloride were administered to rats at a dose of 20 mg/kg body weight. Doxycycline tissue levels were determined using a microbiological assay. Only an insignificant fraction of the antibiotics was found to cross the blood brain barrier. Doxycycline was highly concentrated in excretory organs: liver, kidneys and caecum. The high intestinal drug level observed is probably related to the entero-hepatic cycle of this antibiotic. There was a good correlation between serum and heart doxycycline concentration; heart level was about twice that of serum. In lung, antibiotic level was always higher than in serum.
将两种强力霉素衍生物多磷酸强力霉素和盐酸强力霉素以20毫克/千克体重的剂量给大鼠用药。使用微生物测定法测定强力霉素的组织水平。发现只有极少量的抗生素能穿过血脑屏障。强力霉素在排泄器官（肝脏、肾脏和盲肠）中高度浓缩。观察到的肠道药物水平较高可能与这种抗生素的肠肝循环有关。血清和心脏中强力霉素浓度之间有良好的相关性；心脏中的水平约为血清的两倍。在肺部，抗生素水平始终高于血清。
