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IgM类风湿因子可防止补体介导的免疫沉淀抑制作用。

IgM-RF prevents complement-mediated inhibition of immune precipitation.

作者信息

Mitchell W S, Naama J K, Veitch J, Whaley K

出版信息

Immunology. 1984 Jul;52(3):445-8.

PMID:6745994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1454486/
Abstract

Rheumatoid arthritis (RA) serum inhibits complement-mediated inhibition of immune precipitation (solubilization). We have isolated inhibitory activity from RA sera and shown that it is a property of IgM-rheumatoid factor (IgM-RF) and, to a lesser extent, IgG-RF.

摘要

类风湿性关节炎（RA）血清可抑制补体介导的免疫沉淀抑制作用（溶解作用）。我们已从RA血清中分离出抑制活性，并表明其是IgM类风湿因子（IgM-RF）的特性，在较小程度上也是IgG-RF的特性。

相似文献

1
IgM-RF prevents complement-mediated inhibition of immune precipitation.IgM类风湿因子可防止补体介导的免疫沉淀抑制作用。
Immunology. 1984 Jul;52(3):445-8.
2
Inhibitory effect of IgM rheumatoid factor on immune complex solubilization capacity and inhibition of immune precipitation.IgM类风湿因子对免疫复合物溶解能力的抑制作用及对免疫沉淀的抑制作用。
Arthritis Rheum. 1984 Oct;27(10):1130-6. doi: 10.1002/art.1780271008.
3
Complement mediated inhibition of immune precipitation in rheumatoid arthritis: studies on interaction of heat aggregated IgG with IgM rheumatoid factor.补体介导的类风湿关节炎免疫沉淀抑制作用：热聚集IgG与IgM类风湿因子相互作用的研究
Ann Rheum Dis. 1988 Aug;47(8):675-80. doi: 10.1136/ard.47.8.675.
4
Inhibition of complement-mediated solubilization of antigen-antibody complexes by sera from patients with rheumatoid arthritis.类风湿关节炎患者血清对补体介导的抗原-抗体复合物溶解的抑制作用。
Clin Exp Immunol. 1983 Nov;54(2):429-38.
5
Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester.天冬甜素（一种二肽甲酯）对类风湿因子活性的干扰。
J Mol Recognit. 1999 Jul-Aug;12(4):249-57. doi: 10.1002/(SICI)1099-1352(199907/08)12:4<249::AID-JMR463>3.0.CO;2-B.
6
Enhancement of Clq binding activity by IgM rheumatoid factor.IgM类风湿因子增强Clq结合活性。
J Rheumatol. 1985 Jun;12(3):444-8.
7
Interference of rheumatoid factor activity by aspartame, a dipeptide methyl ester.二肽甲酯阿斯巴甜对类风湿因子活性的干扰。
J Mol Recognit. 1999 Sep-Oct;12(5):249-57.
8
Reduction of the complement activation capacity of soluble IgG aggregates and immune complexes by IgM-rheumatoid factor.IgM类风湿因子降低可溶性IgG聚集体和免疫复合物的补体激活能力。
Immunology. 1985 Jul;55(3):555-64.
9
Circulating immune complexes associated with decreased complement-mediated inhibition of immune precipitation in sera from patients with bacterial endocarditis.循环免疫复合物与细菌性心内膜炎患者血清中补体介导的免疫沉淀抑制作用降低有关。
Clin Exp Immunol. 1986 Feb;63(2):359-66.
10
The roles of IgG, IgM rheumatoid factor, and their complexes in the induction of polymorphonuclear leukocyte chemotactic factor from complement.IgG、IgM类风湿因子及其复合物在从补体诱导多形核白细胞趋化因子中的作用。
J Clin Invest. 1974 Jun;53(6):1503-11. doi: 10.1172/JCI107700.

引用本文的文献

1
Antibody-dependent and -independent mechanisms of inflammatory arthritis.抗体依赖和非依赖的炎症性关节炎发病机制。
JCI Insight. 2019 Mar 7;4(5). doi: 10.1172/jci.insight.125278.
2
Rheumatoid factor and antibodies to cyclic citrullinated peptides are associated with severe extra-articular manifestations in rheumatoid arthritis.类风湿因子和抗环瓜氨酸肽抗体与类风湿关节炎严重的关节外表现相关。
Ann Rheum Dis. 2007 Jan;66(1):59-64. doi: 10.1136/ard.2006.054445. Epub 2006 Aug 10.
3
The plasma protein which inhibits complement-mediated prevention of immune precipitation is an Fc binding protein.

本文引用的文献

1
A comparison of the effects of heat-aggregated and chemically cross-linked IgG on monocyte C2 production.热聚集和化学交联IgG对单核细胞C2产生影响的比较。
Immunology. 1983 Jul;49(3):457-61.
2
Inhibition of immune precipitation by complement.补体对免疫沉淀的抑制作用。
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Inhibition of complement-mediated solubilization of antigen-antibody complexes by sera from patients with rheumatoid arthritis.类风湿关节炎患者血清对补体介导的抗原-抗体复合物溶解的抑制作用。
抑制补体介导的免疫沉淀阻止作用的血浆蛋白是一种Fc结合蛋白。
Immunology. 1989 Jan;66(1):20-5.
4
Recombinant soluble Fc gamma RII inhibits immune complex precipitation.重组可溶性FcγRII抑制免疫复合物沉淀。
Clin Exp Immunol. 1995 Dec;102(3):620-5. doi: 10.1111/j.1365-2249.1995.tb03862.x.
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Complement deficiency and immune complex disease.补体缺陷与免疫复合物疾病
Springer Semin Immunopathol. 1994;15(4):397-416. doi: 10.1007/BF01837367.
6
Reduction of the complement activation capacity of soluble IgG aggregates and immune complexes by IgM-rheumatoid factor.IgM类风湿因子降低可溶性IgG聚集体和免疫复合物的补体激活能力。
Immunology. 1985 Jul;55(3):555-64.
7
An inhibitor of complement-mediated prevention of immune precipitation in rheumatoid arthritis--relationship to disease activity and systemic manifestations.类风湿关节炎中补体介导的免疫沉淀抑制因子——与疾病活动度及全身表现的关系
Rheumatol Int. 1986;6(5):209-13. doi: 10.1007/BF00541369.
8
Circulating immune complexes associated with decreased complement-mediated inhibition of immune precipitation in sera from patients with bacterial endocarditis.循环免疫复合物与细菌性心内膜炎患者血清中补体介导的免疫沉淀抑制作用降低有关。
Clin Exp Immunol. 1986 Feb;63(2):359-66.
9
Inhibition of C1q binding to antigen-antibody complexes by a factor in rheumatoid arthritis serum.类风湿关节炎血清中的一种因子对C1q与抗原-抗体复合物结合的抑制作用。
Rheumatol Int. 1986;6(5):205-8. doi: 10.1007/BF00541368.
10
Purification of a plasma protein that inhibits complement-mediated prevention of immune precipitation.一种抑制补体介导的免疫沉淀预防作用的血浆蛋白的纯化
Immunology. 1988 May;64(1):45-50.
Clin Exp Immunol. 1983 Nov;54(2):429-38.
4
Complement-mediated inhibition of immune precipitation in patients with immune complex diseases.补体介导的免疫复合物疾病患者免疫沉淀抑制作用
Clin Exp Immunol. 1983 Feb;51(2):292-8.
5
Complement fixation by the F(ab')2-fragment of pepsin-treated rabbit antibody.经胃蛋白酶处理的兔抗体的F(ab')2片段的补体结合
Immunology. 1971 May;20(5):649-58.
6
Immunopathologic study of sural nerves in rheumatoid arthritis.类风湿关节炎中腓肠神经的免疫病理学研究
Arthritis Rheum. 1972 Mar-Apr;15(2):135-43. doi: 10.1002/art.1780150202.
7
Affinity labeling of a mouse myeloma protein which binds nitrophenyl ligands. Kinetics of labeling and isolation of a labeled peptide.结合硝基苯基配体的小鼠骨髓瘤蛋白的亲和标记。标记动力学及标记肽段的分离
Biochemistry. 1970 Mar 3;9(5):1267-78. doi: 10.1021/bi00807a031.
8
A method of trace iodination of proteins for immunologic studies.一种用于免疫学研究的蛋白质微量碘化方法。
Int Arch Allergy Appl Immunol. 1966;29(2):185-9. doi: 10.1159/000229699.
9
Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease.类风湿关节炎患者的循环及关节内免疫复合物。125I-Clq结合活性与疾病临床及生物学特征的相关性。
J Clin Invest. 1976 May;57(5):1308-19. doi: 10.1172/JCI108399.