Colditz I G, Movat H Z
Immunol Lett. 1984;8(2):83-7. doi: 10.1016/0165-2478(84)90055-5.
The accumulation of polymorphonuclear leukocytes (PMNs) was measured in rabbits following single or repeated injections into skin sites of the inflammatory agents, zymosan-activated plasma and formylmethionyl-leucyl-phenylalanine. Fewer cells entered lesions restimulated with the same agent during the subsequent inflammatory response than simultaneously entered skin sites stimulated for the first time. Decreased reactivity of a restimulated site was specific to the initiating stimulus, developed within 2 to 4 h of initial stimulation and persisted for at least 8 h. The results indicate that PMN accumulation in acute inflammatory lesions is regulated locally by a chemotactic factor-specific mechanism which differs from PMN deactivation and concentration gradient mechanisms currently thought to regulate PMN migration in vivo.
在兔子皮肤部位单次或重复注射炎症介质酵母聚糖激活血浆和甲酰甲硫氨酰-亮氨酰-苯丙氨酸后，检测多形核白细胞（PMN）的聚集情况。在随后的炎症反应中，用相同介质再次刺激的损伤部位进入的细胞比首次刺激的皮肤部位同时进入的细胞少。再次刺激部位反应性降低是起始刺激所特有的，在初始刺激后2至4小时内出现，并持续至少8小时。结果表明，急性炎症损伤中PMN的聚集受趋化因子特异性机制的局部调节，该机制不同于目前认为在体内调节PMN迁移的PMN失活和浓度梯度机制。
