白细胞介素-1在内毒素诱导的中性粒细胞迁移中的作用。
The role of interleukin-1 in neutrophil leukocyte emigration induced by endotoxin.
作者信息
Cybulsky M I, Colditz I G, Movat H Z
出版信息
Am J Pathol. 1986 Sep;124(3):367-72.
Abstract
Chemotactic factors induce neutrophil emigration into tissues. Interleukin-1 (IL-1) was found to be several log times more potent in this respect than C5a des Arg, leukotriene B4, and f-Met-Leu-Phe and of comparable potency to endotoxin. Kinetic studies revealed a rapid and transient neutrophil influx, with the peak rate at 30-90 minutes. Cross tachyphylaxis was observed between IL-1 and endotoxin; and this, together with its high potency and rapid onset of action, suggest that IL-1 mediates endotoxin-induced neutrophil emigration.
摘要
趋化因子诱导中性粒细胞向组织内游走。白细胞介素-1（IL-1）在这方面的效力比C5a去精氨酸、白三烯B4和f-甲硫氨酰-亮氨酰-苯丙氨酸强几个对数级，与内毒素的效力相当。动力学研究显示中性粒细胞快速且短暂地流入，峰值速率出现在30 - 90分钟。在IL-1和内毒素之间观察到交叉快速耐受性；这一点，连同其高效力和快速起效，表明IL-1介导内毒素诱导的中性粒细胞游走。
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