Mertz W
Fed Proc. 1982 Sep;41(11):2807-12.
Although there is no evidence for a direct cause-effect relationship between mineral and trace element status and atherosclerosis in humans, many elements exert a strong influence on individual risk factors for cardiovascular disease, such as disorders of blood lipids, blood pressure, coagulation, glucose tolerance, and circulating insulin. Studies in humans and animals have shown that optimal intakes of elements such as sodium, magnesium, calcium, chromium, copper, zinc, and iodine can reduce individual risk factors; some of these studies are consistent with the results of epidemiologic correlations. Influences of local geochemical environment and of dietary practices can result in mineral and trace element imbalances; deficiencies of chromium, iron, copper, zinc, selenium, and iodine are well defined. Detection and correction of such imbalances in populations, through diminishing individual risk factors, might ultimately reduce the incidence of atherosclerotic heart disease.
虽然尚无证据表明矿物质和微量元素状况与人类动脉粥样硬化之间存在直接的因果关系，但许多元素对心血管疾病的个体风险因素有很大影响，如血脂紊乱、血压、凝血、葡萄糖耐量和循环胰岛素。对人类和动物的研究表明，钠、镁、钙、铬、铜、锌和碘等元素的最佳摄入量可降低个体风险因素；其中一些研究与流行病学相关性结果一致。当地地球化学环境和饮食习惯的影响可能导致矿物质和微量元素失衡；铬、铁、铜、锌、硒和碘的缺乏已得到明确界定。通过减少个体风险因素来检测和纠正人群中的此类失衡，最终可能降低动脉粥样硬化性心脏病的发病率。
