Kawata M, Hashimoto K, Takahara J, Sano Y
Anat Embryol (Berl). 1982 Dec;165(3):303-13. doi: 10.1007/BF00305569.
The presence of the CRF-containing neurons in the hypothalamus was investigated in four different species (cats, dogs, pigs, and monkeys) by the peroxidase-antiperoxidase technique using specific antiserum to CRF. In all animals examined, CRF-containing perikarya were found mainly in the paraventricular and supraoptic nuclei, and a small number of the immunoreactive cells were observed in the accessory supraoptic nucleus and the lateral hypothalamic area. The size of the CRF-containing perikarya ranged from 20-35 micron in diameter. These findings suggest that the magnocellular paraventricular and supraoptic nuclei are the center not only of the classical neurosecretory system for the production of the posterior lobe hormones, but also that of the CRF neuronal system.
采用抗促肾上腺皮质激素释放因子（CRF）特异性抗血清，运用过氧化物酶抗过氧化物酶技术，在四种不同物种（猫、狗、猪和猴子）中研究了下丘脑内含有CRF的神经元的存在情况。在所有被检查的动物中，含CRF的核周体主要见于室旁核和视上核，并且在视上核旁核和下丘脑外侧区观察到少量免疫反应性细胞。含CRF的核周体直径大小在20 - 35微米之间。这些发现表明，大细胞性室旁核和视上核不仅是产生后叶激素的经典神经分泌系统的中心，也是CRF神经元系统的中心。
