多种自身免疫性疾病中免疫复合物的检测及其与类风湿因子的关系。
Detection of immune complexes and their relationship to rheumatoid factor in a variety of autoimmune disorders.
作者信息
Pope R M, Yoshinoya S, McDuffy S J
出版信息
Clin Exp Immunol. 1981 Nov;46(2):259-67.
The sera of patient with adult rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD) were employed together with sensitive radioimmunoassays to examine the relationship between immune complexes detected by three methods and the IgM, IgA and IgG classes of rheumatoid factors (RF). Compared to the controls, significantly increased concentrations of RF and immune complexes were detected for every patient group except JRA. Increased concentrations of IgA RF, IgG RF and immune complexes detected by the C1qBA and the C1qSP were strongly associated with the presence of IgM RF. Significant correlations were noted between RF (especially IgG and IgM) and immune complexes (detected by both the C1qBA and the C1qSP) for patients with RA, SLE and MCTD. These studies suggest that RF may be partially involved in the formation of the immune complexes detected by C1q-binding assays and demonstrate the need for further clarification of the constituents of the immune complexes detected in each disease.
采用灵敏的放射免疫分析法，对成年类风湿性关节炎（RA）、青少年类风湿性关节炎（JRA）、系统性红斑狼疮（SLE）和混合性结缔组织病（MCTD）患者的血清进行检测，以研究三种方法检测到的免疫复合物与类风湿因子（RF）的IgM、IgA和IgG类之间的关系。与对照组相比，除JRA外，每个患者组的RF和免疫复合物浓度均显著升高。通过C1qBA和C1qSP检测到的IgA RF、IgG RF和免疫复合物浓度升高与IgM RF的存在密切相关。对于RA、SLE和MCTD患者，RF（尤其是IgG和IgM）与免疫复合物（通过C1qBA和C1qSP检测）之间存在显著相关性。这些研究表明，RF可能部分参与了通过C1q结合试验检测到的免疫复合物的形成，并表明需要进一步阐明每种疾病中检测到的免疫复合物的成分。
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