Környey S
Acta Neuropathol. 1978 Aug 7;43(1-2):179-83. doi: 10.1007/BF00685013.
The light microscopic changes of the first human case in which electron microscopic identification of the virus was successful, are described. They are compared with the findings accepted in the literature as characteristic of tick-borne encephalitis. Although meningeal and intracerebral infiltrations were partly connected, the process cannot be regarded as a meningoencephalitis. The choroid plexus remained free from infiltration. The discontinuous inflammatory process was severe in the cerebral cortex in the pre-central region, further in the temporal lobe, and became even more accentuated in the amygdaloid nucleus. Reduction in the number of nerve cells could be ascertained chiefly in the motor cortex. The tick-borne encephalitis belongs to the group of disseminated polioencephalitides with predilection site in the brain stem, all of them caused by ribonucleic acid viruses, irrespective of whether the virus belongs to the families of Picorna-, Toga-, or Rhabdoviruses. Within this histologically outlined group the individual entities possess distinctive traits. The significance of the anoxic-vasal factor in the process formation is displayed on the instance of some traits of the histological pictures.
本文描述了首例通过电子显微镜成功鉴定出病毒的人类病例的光学显微镜下变化。将这些变化与文献中公认的蜱传脑炎特征进行了比较。尽管脑膜和脑内浸润部分相关，但该过程不能被视为脑膜脑炎。脉络丛未出现浸润。间断性炎症过程在中央前区的大脑皮层严重，在颞叶较轻，在杏仁核则更为明显。神经细胞数量减少主要见于运动皮层。蜱传脑炎属于脑干为好发部位的播散性脑灰质炎组，所有这些疾病均由核糖核酸病毒引起，无论该病毒属于小核糖核酸病毒科、披膜病毒科还是弹状病毒科。在这个组织学界定的组内，各个实体具有独特特征。缺氧-血管因素在病变形成过程中的作用在组织学图像的某些特征中得以体现。
