免疫球蛋白重链可变区基因对抗体多样性的贡献。
Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversity.
作者信息
Rabbitts T H, Matthyssens G, Hamlyn P H
出版信息
Nature. 1980 Mar 20;284(5753):238-43. doi: 10.1038/284238a0.
DOI:10.1038/284238a0
PMID:6767191
Abstract
A mouse cloned cDNA probe containing a variable (V) region belonging to the VHIII subgroup has been used in filter hybridisations to estimate the number of heavy-chain V-genes in this subgroup of mouse and human DNA. There seem to be about 10 and 20 VH-genes hybridising to this probe in mouse and human DNA, respectively. Studies of cross-hybridisation of the related VK-genes from MOPC21 and MPC11 myelomas indicate that the experiments detect all members of the VHIII subgroup.
摘要
一个包含属于VHIII亚组可变（V）区的小鼠克隆cDNA探针已用于滤膜杂交，以估计该小鼠和人类DNA亚组中重链V基因的数量。在小鼠和人类DNA中，分别似乎有大约10个和20个VH基因与该探针杂交。对来自MOPC21和MPC11骨髓瘤的相关VK基因的交叉杂交研究表明，这些实验检测到了VHIII亚组的所有成员。
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