克罗米芬治疗特发性生育力低下男性：大剂量隔日疗法。

Clomiphene treatment of the idiopathic hypofertile male: high-dose, alternate-day therapy.

作者信息

Ross L S, Kandel G L, Prinz L M, Auletta F

出版信息

Fertil Steril. 1980 Jun;33(6):618-23. doi: 10.1016/s0015-0282(16)44775-8.

Abstract

Increasing reports suggest that clomiphene citrate (clomid) is useful in the treatment of idiopathic hypofertile males. Recent studies have advocated low-dose, cyclic therapy (25 mg daily for 25 days, 5 days' rest) and, although significant clinical responses have been reported, the hormone response has been erratic. This study of 53 patients, given high-dose, alternate-day therapy (100 mg three times/week), shows an over-all positive response rate of 66% and a pregnancy rate of 26%. Significant gonadotropin and testosterone surges were seen in the responders, but a selective lack of a follicle-stimulating hormone surge was noted in a small group of nonresponders. Clomiphene given in this dosage seems to be safe for periods of up to 15 months and appears to be a rational and useful agent for the treatment of this patient group.

摘要

越来越多的报告表明，枸橼酸氯米芬（克罗米酚）对特发性生育力低下的男性治疗有效。近期研究提倡采用低剂量、周期性疗法（每日25毫克，共25天，休息5天），尽管已有显著临床反应的报道，但激素反应却不稳定。这项对53例患者进行的研究采用高剂量、隔日疗法（每周三次，每次100毫克），总体阳性反应率为66%，妊娠率为26%。有反应者出现了显著的促性腺激素和睾酮激增，但一小部分无反应者存在选择性促卵泡激素激增缺乏的情况。该剂量的氯米芬使用长达15个月似乎是安全的，且似乎是治疗该患者群体的一种合理且有效的药物。