Sachse G, Willms B
Horm Metab Res Suppl. 1980;9:105-7.
The therapeutic efficacy of thioctic acid was studied in patients with peripheral diabetic neuropathy. In a double-blind study ten diabetics were treated with thioctic acid or a placebo for 21 days. In a second study ten diabetics were also treated with thioctic acid intravenously (i.v.) for 21 days. Before and on the 11th and 21st day of treatment, we examined the clinical neurological state, the vibration sense according to biothesiometry, the nerve conduction velocity, and the degree of diabetic control. In addition the patients were asked about neuropathic complaints. The therapeutic efficacy of oral or i.v. thioctic acid could not be verified by measurements of the nerve conduction velocity or the vibration sensibility. No effect of oral thioctic acid on subjective complaints was observed. However, i.v. treatment with thioctic acid resulted in a distinct improvement of subjective complaints.
研究了硫辛酸对糖尿病周围神经病变患者的治疗效果。在一项双盲研究中，10名糖尿病患者接受硫辛酸或安慰剂治疗21天。在第二项研究中，10名糖尿病患者也接受了21天的静脉注射硫辛酸治疗。在治疗前以及治疗的第11天和第21天，我们检查了临床神经状态、根据生物感觉测量法测定的振动觉、神经传导速度以及糖尿病控制程度。此外，还询问了患者有关神经病变的主诉。通过测量神经传导速度或振动觉，无法证实口服或静脉注射硫辛酸的治疗效果。未观察到口服硫辛酸对主观主诉有任何影响。然而，静脉注射硫辛酸治疗使主观主诉有明显改善。
