Constable I J, Slatter D H, Horne R
Invest Ophthalmol Vis Sci. 1980 Jun;19(6):603-9.
A simplified practical technique for biopsy of retina and choroid has been developed in dogs. A 270 degree circular scleral flap of 3 mm diameter is raised. The risks of chorioretinal bleeding and vitreous loss are greatly reduced by intravenous mannitol and controlled hyperventilation, with hyperoxygenation and transient, systemic hypotension under general anesthesia. Rreasonable ultrastructural detail was preserved in chorioretinal specimens of 1 mm diameter. Repeat biopsies in the same eye are feasible without significant complications.
已经在犬类中开发出一种用于视网膜和脉络膜活检的简化实用技术。制作一个直径3毫米的270度圆形巩膜瓣。通过静脉注射甘露醇和控制性过度通气，在全身麻醉下进行高氧合和短暂性全身性低血压，可大大降低脉络膜视网膜出血和玻璃体丢失的风险。直径1毫米的脉络膜视网膜标本中保留了合理的超微结构细节。同一只眼睛重复活检是可行的，且无明显并发症。
