Griffin J R, Straatsma B R, Kreiger A E
Mod Probl Ophthalmol. 1975;15:272-8.
A technique for transvitreal chorioretinal biopsy has been developed which employs a stereotaxic intraocular micromanipulator and a newly designed biopsy instrument. Biopsy is performed by trephinating and removing from the eye a 1.5-mm diameter specimen of posterior eye wall. Hemostasis and chorioretinal adhesion are achieved by mechanical compression of the tissues surrounding the eye wall defect. The eye wall defect is sealed by a preplaced silicone explant and repaired by fibrovascular ingrowth from the surrounding choroid and episclera. Normal histological features of the biopsy specimen are preserved except for edema of the tissues, separation of the neurosensory retina from the pigmented epithelium, and occasional hemorrhagic detachment of the pigmented epithelium.
一种经玻璃体脉络膜视网膜活检技术已经开发出来，该技术采用立体定向眼内显微操作器和新设计的活检器械。活检通过环钻并从眼内取出直径1.5毫米的后眼球壁标本进行。通过对眼球壁缺损周围组织进行机械压迫来实现止血和脉络膜视网膜粘连。眼球壁缺损由预先放置的硅胶植入物封闭，并通过周围脉络膜和巩膜的纤维血管长入进行修复。活检标本的正常组织学特征得以保留，除了组织水肿、神经感觉视网膜与色素上皮分离以及色素上皮偶尔的出血性脱离。
