Saunders J H, Thjodleifsson B, Wormsley K G
Gut. 1976 Jun;17(6):435-8. doi: 10.1136/gut.17.6.435.
Magnesium sulphate has previously been used as a purgative in a test involving the measurement of the faecal excretion of pancreatic enzymes. In order to validate the use of magnesium sulphate for this purpose, in 18 individuals the pancreatic and biliary response to intravenous infusion of secretin (1 CU/kg-h) plus CCK(1IU/kg-h) were compared with the responses to one of three dose-rates of magnesium sulphate infused into the duodenum. The effect of magnesium sulhphate was also studied during the coincident intravenous administration of the hormones. Intraduodenal magnesium sulphate did not stimulate the secretion of bicarbonate into the duodenum but did evoke the secretion of pancreatic enzymes and discharge of bile. The pancreatic response to the exogenous hormones was not altered by coincident intraduodenal infusion of magnesium sulphate. We conclude that magnesium sulphate is a satisfactory purgative for speeding the intestinal transit of pancreatic enzymes.
硫酸镁曾在一项涉及测量胰腺酶粪便排泄量的试验中用作泻药。为了验证硫酸镁在此用途上的有效性,在18名个体中,将静脉输注促胰液素(1 CU/kg·h)加胆囊收缩素(1 IU/kg·h)时胰腺和胆汁的反应,与十二指肠内输注三种剂量率之一的硫酸镁后的反应进行了比较。还研究了在同时静脉注射这些激素期间硫酸镁的作用。十二指肠内硫酸镁不会刺激十二指肠内碳酸氢盐的分泌,但会引起胰腺酶的分泌和胆汁的排出。同时十二指肠内输注硫酸镁不会改变胰腺对外源性激素的反应。我们得出结论,硫酸镁是一种令人满意的泻药,可加速胰腺酶在肠道中的转运。