Sanger D J
Psychopharmacology (Berl). 1980;68(3):305-9. doi: 10.1007/BF00428121.
Previous research has shown that benzo-diazepines and barbiturates can increase the proportion of response bursts emitted by rats on differential reinforcement of low rate (DRL) schedules. A recent report found that caffeine could exert a similar effect in mice and the present study was carried out to compare the actions of caffeine with those of chlordiazepoxide on DRL responding in rats and Mongolian gerbils. Chlordiazepoxide increased response rates, decreased reinforcement frequencies and increased percentages of response bursts in both species. Caffeine also increased response rates and decreased reinforcement frequencies, but in neither species was the percentage of response bursts systematically increased. d-Amphetamine administered to the gerbils also did not increase the percentages of response bursts. Combinations of caffeine and chlordiazepoxide were administered to the rats and produced effects which were generally additive.
先前的研究表明，苯二氮䓬类药物和巴比妥类药物可增加大鼠在低比率差别强化（DRL）程序下发出的反应串比例。最近一份报告发现，咖啡因对小鼠可产生类似作用，本研究旨在比较咖啡因与氯氮卓对大鼠和蒙古沙鼠DRL反应的作用。氯氮卓增加了两种动物的反应率，降低了强化频率，并增加了反应串百分比。咖啡因也增加了反应率并降低了强化频率，但在两种动物中，反应串百分比均未系统性增加。给沙鼠注射右旋苯丙胺也未增加反应串百分比。给大鼠注射咖啡因和氯氮卓的组合，产生的效应通常是相加的。
