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铜绿假单胞菌对羧苄青霉素、甘氨酸和乙二胺四乙酸组合的体外敏感性

In vitro susceptibility of Pseudomonas aeruginosa to carbenicillin, glycine, and ethylenediaminetetraacetic acid combinations.

作者信息

Gerberick G F, Castric P A

出版信息

Antimicrob Agents Chemother. 1980 Apr;17(4):732-5. doi: 10.1128/AAC.17.4.732.

DOI:10.1128/AAC.17.4.732
PMID:6772096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283861/
Abstract

Striking bacterial activity against Pseudomonas aeruginosa 9D-2 was achieved by glycine-carbenicillin, ethylenediaminetetraacetic acid-carbenicillin, and glycine-ethylenediaminetetraacetic acid combinations, whereas none of the agents used alone was capable of the same degree of bactericidal activity. Studies using a microtiter modification of the checkerboard technique were performed to evaluate the comparative activity of these antimicrobial combinations. Isobolograms showed synergistic effects with carbenicillin-glycine, carbenicillin-ethylene-diaminetetraacetic acid, and glycine-ethylenediaminetetraacetic acid combinations. Bacterial growth inhibitory curves with subinhibitory concentrations of these agents in combination confirmed these findings.

摘要

甘氨酸-羧苄青霉素、乙二胺四乙酸-羧苄青霉素以及甘氨酸-乙二胺四乙酸组合对铜绿假单胞菌9D-2具有显著的抗菌活性，而单独使用这些药剂均无法达到相同程度的杀菌活性。采用棋盘法的微量滴定法改良技术进行研究，以评估这些抗菌组合的相对活性。等效线图显示羧苄青霉素-甘氨酸、羧苄青霉素-乙二胺四乙酸以及甘氨酸-乙二胺四乙酸组合具有协同作用。这些药剂亚抑菌浓度联合使用时的细菌生长抑制曲线证实了这些发现。

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