Patel P J
Infect Immun. 1980 Jul;29(1):59-65. doi: 10.1128/iai.29.1.59-65.1980.
The site of a delayed hypersensitivity reaction to tuberculin or bovine serum ablumin was shown to contain mechanisms that expressed increased antibacterial activity, as evidenced by restricted growth of a local inoculum of Listeria monocytogenes. As was the case with a delayed hypersensitivity reaction, the local generation of antibacterial activity was antigen specific and T-cell dependent. Antibacterial resistance was always expressed at the site of injection of specific antigen in sensitized mice, even though under certain circumstances there was no measurable increase in footpad thickness at this site. It thus appears that nonspecific antibacterial resistance represents a sensitive and quantitative method for measuring delayed hypersensitivity. More importantly, this study serves to provide a functional meaning for the delayed-type hypersensitivity reaction in that it demonstrates that such a reaction causes the focusing of mechanisms that can restrict the growth of bacteria at a site which may represent a source of microbial invasion.
对结核菌素或牛血清白蛋白迟发型超敏反应的部位显示含有表达增强抗菌活性的机制，这由局部接种的单核细胞增生李斯特菌生长受限证明。与迟发型超敏反应的情况一样，抗菌活性的局部产生是抗原特异性且依赖T细胞的。在致敏小鼠中，抗菌抗性总是在注射特异性抗原的部位表达，即使在某些情况下该部位的足垫厚度没有可测量的增加。因此，非特异性抗菌抗性似乎是测量迟发型超敏反应的一种灵敏且定量的方法。更重要的是，这项研究为迟发型超敏反应提供了功能意义，因为它表明这种反应会使能够限制细菌生长的机制集中在一个可能代表微生物入侵源的部位。
