Yamamoto M, Meyer J S, Sakai F, Yamaguchi F
Arch Neurol. 1980 Aug;37(8):489-96. doi: 10.1001/archneur.1980.00500570037005.
Cerebral vasodilator responses to hypercarbia were tested during inhalation of 5% CO2 in air by normal volunteers with and without risk factors for cerebral atherosclerosis. The results were compared with those of patients with hemispheric infarction or ischemia or vertebrobasilar arterial insufficiency (VBI). Regional cerebral blood flow was measured by the 133Xe inhalation method before and during hypercarbia. Responsiveness to CO2 was expressed as the percentage increase of gray matter flow per mm Hg of end-tidal CO2 tension. Cerebral vasodilator responsiveness is mildly impaired by the atherosclerosis of normal aging, is moderately impaired in normal subjects with risk factors for cerebral atherosclerosis, and is greatly impaired in patients with symptomatic hemispheric ischemia and VBI. Testing regional cerebral blood flow with CO2 appears to be a useful, harmless screening test for cerebral atherosclerosis.
在吸入含5%二氧化碳的空气期间，对有和没有脑动脉粥样硬化危险因素的正常志愿者进行了高碳酸血症引起的脑血管扩张反应测试。将结果与半球梗死或缺血或椎基底动脉供血不足（VBI）患者的结果进行比较。在高碳酸血症之前和期间，通过吸入133Xe法测量局部脑血流量。对二氧化碳的反应性以每毫米汞柱潮气末二氧化碳分压时灰质血流量增加的百分比来表示。正常衰老的动脉粥样硬化会轻度损害脑血管扩张反应性，有脑动脉粥样硬化危险因素的正常受试者会中度受损，有症状性半球缺血和VBI的患者会严重受损。用二氧化碳测试局部脑血流量似乎是一种用于脑动脉粥样硬化的有用、无害的筛查测试。
