Wink C S, Felts W J
Calcif Tissue Int. 1980;32(1):77-82. doi: 10.1007/BF02408524.
Forty young (23-day-old) and thirty old (1-year-old) male rats were castrated and sacrificed with controls at intervals up to 18 months of age. No differences were observed between femurs or mandibles of rats castrated at 23 days and those of controls. Year-old castrate rats developed femoral osteoporosis after 2 months, which became more pronounced 4 months after castration. This was characterized by reductions in femoral density, dry weight, dry weight per unit length, and ash weight, and by the appearance of resorption cavities in diaphyseal walls and a sparsity of trabeculae in metaphyses and epiphyses of castrate femurs. These results indicate that the year-old castrate male rat may be a valuable experimental model for studies of the treatment of osteoporosis.
将40只年轻（23日龄）和30只年老（1岁）雄性大鼠去势，并与对照组在长达18个月龄的时间间隔内处死。23日龄去势大鼠的股骨和下颌骨与对照组之间未观察到差异。1岁去势大鼠在2个月后出现股骨骨质疏松，在去势4个月后更为明显。其特征为股骨密度、干重、单位长度干重和灰分重量降低，以及去势股骨骨干壁出现吸收腔，干骺端和骨骺小梁稀疏。这些结果表明，1岁去势雄性大鼠可能是研究骨质疏松症治疗的有价值的实验模型。
