Oliveira R B, Troncon L E, Meneghelli U G, Padovan W, Dantas R O, de Godoy R A
Dig Dis Sci. 1980 Oct;25(10):790-4. doi: 10.1007/BF01345301.
In order to evaluate the contribution of the myenteric plexuses to the control of gastric accommodation to distension and to the rate of gastric emptying of a saline solution in man, we have evaluated these functions in patients with Chagas' disease, which is known to be associated with extensive lesions of the myenteric plexuses. Intragastric pressure was significantly higher (P < 0.05) in Chagas patients (N = 15) than in normal controls (N = 15) for air distension volumes of 100-700 ml. In the range 300-700 ml, the difference between the groups was approximately twofold (P < 0.001). The gastric emptying rate of 500 ml 154 mM NaCl in a second group of Chagas' disease patients (N = 13) was significantly faster than that of the control group (N = 17) at 5 min (P < 0.005) and at 15 min (P < 0.005) after the test meal, but at 25 min the volumes remaining in the stomach were not statistically significant for the two groups (P > 0.10). The impairment of gastric accommodation to distension and consequent rapid gastric emptying demonstrated for chagasic patients emphasizes the role of the myenteric plexuses in gastric reservoir function in man and complements previous evidence obtained in animal studies.
为了评估肌间神经丛对人体胃扩张适应性及盐溶液胃排空速率的控制作用，我们对患有恰加斯病的患者的这些功能进行了评估，已知恰加斯病与肌间神经丛的广泛病变有关。对于100 - 700毫升的空气扩张量，恰加斯病患者（N = 15）的胃内压显著高于正常对照组（N = 15）（P < 0.05）。在300 - 700毫升范围内，两组之间的差异约为两倍（P < 0.001）。在第二组恰加斯病患者（N = 13）中，500毫升154 mM NaCl的胃排空速率在试餐后5分钟（P < 0.005）和15分钟（P < 0.005）时显著快于对照组（N = 17），但在25分钟时，两组胃内剩余体积无统计学差异（P > 0.10）。恰加斯病患者胃扩张适应性受损及随之而来的快速胃排空表明了肌间神经丛在人体胃储存功能中的作用，并补充了先前在动物研究中获得的证据。
