Grupper C H, Berretti B, Schnitzler L, Bensoussan D
Ann Dermatol Venereol. 1978 Mar;105(3):291-8.
A group of 18 patients with mycosis fungoides (M.F.) was treated by PUVAtherapy. According to VanScott classification, they have been set in:--5 parapsoriasis in large plaques = 5 stages I;--6 stages II;--3 stages III;--2 stages IV;--1Sézary syndrom.--1 erythrodermia. There was complete clearing of 12 patients (66 p. 100); 2 patients (11 p. 100) improved cutaneous lesions without a complete clearing, and there was no response to treatment for 3 patients (22 p. 100) (1 with erythrodermia, 1 with Sézary syndrom and 1 stage IV, and 1 forsaking). The method applied here was different in several points: orally administered methoxalen were given according to the body area (mg/m2) and some of the patients had twice a day puvatherapy. Puvatherapy seems to be the least dangerous and most effective treatment for the patients in the early stages of mycosis fongoides (I, II) and nitrogen mustard, electron therapy, corticoids and even mono- or polychimiotherapy could be associated to puvatherapy, if necessary, for the stages III and IV.
一组18例蕈样肉芽肿（MF）患者接受了补骨脂素加长波紫外线（PUVA）治疗。根据范斯科特分类，他们被分为：——5例大斑块状副银屑病=5例I期；——6例II期；——3例III期；——2例IV期；——1例塞扎里综合征。——1例红皮病。12例患者（66%）完全缓解；2例患者（11%）皮肤病变有所改善但未完全缓解，3例患者（22%）对治疗无反应（1例红皮病、1例塞扎里综合征、1例IV期，1例放弃治疗）。此处应用的方法在几个方面有所不同：根据体表面积（mg/m2）口服甲氧沙林，部分患者每天接受两次PUVA治疗。PUVA治疗似乎是蕈样肉芽肿早期（I、II期）患者最安全且最有效的治疗方法，对于III期和IV期患者，如有必要，氮芥、电子治疗、皮质类固醇甚至单药或多药化疗可与PUVA治疗联合使用。
