Henriksen J H, Brøchner-Mortensen J, Malchow-Møller A, Schlichting P
Scand J Clin Lab Invest. 1980 May;40(3):279-84. doi: 10.3109/00365518009095579.
The total plasma (Clt) and the renal plasma (Clr) clearances of [51Cr]EDTA were determined simultaneously in nine patients with ascites due to liver cirrhosis. Clt (mean 78 ml/min, range 34-115 ml/min) was significantly higher than Clr (mean 52 ml/min, range 13-96 ml/min, P < 0.005). The ascitic fluid-plasma activity ratio of [51Cr]EDTA increased throughout the investigation period (5h). The results suggest that [51Cr]EDTA equilibrates slowly with the peritoneal space which indicates that Clt will over-estimate the glomerular filtration rate by approximately 20 ml/min in patients with ascites. To assess glomerular filtration rate in presence of ascites, the renal plasma clearance of [51Cr]EDTA should be used instead of the total plasma clearance.
在9例肝硬化腹水患者中，同时测定了[51Cr]依地酸二钠（[51Cr]EDTA）的总血浆清除率（Clt）和肾血浆清除率（Clr）。Clt（平均78 ml/分钟，范围34 - 115 ml/分钟）显著高于Clr（平均52 ml/分钟，范围13 - 96 ml/分钟，P < 0.005）。在整个研究期间（5小时），[51Cr]EDTA的腹水 - 血浆活性比值升高。结果表明，[51Cr]EDTA与腹膜腔的平衡缓慢，这表明在腹水患者中，Clt会高估肾小球滤过率约20 ml/分钟。为评估存在腹水时的肾小球滤过率，应使用[51Cr]EDTA的肾血浆清除率而非总血浆清除率。
