Suzuki J, Tanaka S, Yoshimoto T, Seki H
Acta Neurochir (Wien). 1980;54(3-4):219-31. doi: 10.1007/BF01407089.
Using our previously published "incomplete cerebral hemispheric infarction model in dogs" (produced by simultaneous ipsilateral occlusions of the anterior cerebral artery at the branching of the ethmoidal artery from its A1 portion, the A2 portion, the internal carotid artery, the posterior communication artery, the posterior cerebral artery, and the anterior cerebellar artery), two, four, or six hours occlusion of blood flow was undertaken. Observations were then made on the degree of brain swelling following recirculation due to administration of mannitol or glycerol solutions. Furthermore, the leakage of Evans blue was investigated to determine the damage to the blood brain barrier. 1. In the animals given mannitol or glycerol, brain swelling was suppressed, following two hours occlusion, In the animals given mannitol, however, brain swelling was not suppressed after four or six hours occlusion. 2. After two hours occlusion in the animals given mannitol, leakage of Evans blue was slight compared with the untreated group. In the six hours occlusion groups, severe leakage of Evans blue was seen in both the untreated animals and the mannitol-treated. After two hours occlusion, in some animals which had been given glycerol, severe leakage of Evans blue was seen, even when there was little brain swelling.
利用我们之前发表的“犬不完全性大脑半球梗死模型”（通过同时夹闭筛动脉从其A1段、A2段分支处的大脑前动脉、颈内动脉、后交通动脉、大脑后动脉以及小脑前动脉的同侧血流而产生），进行了两小时、四小时或六小时的血流阻断。然后观察给予甘露醇或甘油溶液后再灌注时的脑肿胀程度。此外，研究伊文思蓝的渗漏情况以确定血脑屏障的损伤。1. 在给予甘露醇或甘油的动物中，两小时阻断后脑肿胀得到抑制。然而，在给予甘露醇的动物中，四小时或六小时阻断后脑肿胀未得到抑制。2. 在给予甘露醇的动物中，两小时阻断后，与未治疗组相比，伊文思蓝的渗漏轻微。在六小时阻断组中，未治疗动物和甘露醇治疗动物均出现严重的伊文思蓝渗漏。两小时阻断后，在一些给予甘油的动物中，即使脑肿胀轻微，也出现了严重的伊文思蓝渗漏。
