Tanaka S, Seki H, Yoshimoto T, Suzuki J
No To Shinkei. 1981 Nov;33(11):1141-6.
We have developed and previously reported a canine model for diffuse, incomplete cerebral hemisphere infarction produced by simultaneously occluding the following 5 arteries unilaterally at the base of the brain: the A2 portion of the anterior cerebral artery, the A1 portion of the anterior cerebral artery at the bifurcation of the ethmoidal artery, the internal carotid artery, the posterior cerebral artery at the bifurcation of the posterior communicating artery and the anterior cerebellar artery. After 6 hours of occlusion, recirculation was allowed, and sequential observation was made on the degree of brain swelling. Investigation was made on whether or not administration of 20% mannitol or fluorocarbon emulsion (20% fluosol DA) following vascular occlusion is effective in suppressing such swelling. It was found that brain swelling could be prevented using by mannitol and fluorocarbon emulsion together, but not mannitol and fluorocarbon emulsion alone. Based on these results, we found that mannitol administered together with fluorocarbon emulsion has a protective effect for cerebral infarction following 6 hours vascular occlusion.
我们已经开发并在之前报道过一种犬类模型，该模型通过在脑底部单侧同时闭塞以下5条动脉来产生弥漫性、不完全性大脑半球梗死：大脑前动脉的A2段、筛动脉分叉处的大脑前动脉A1段、颈内动脉、后交通动脉分叉处的大脑后动脉以及小脑前动脉。闭塞6小时后，允许再灌注，并对脑肿胀程度进行连续观察。研究了血管闭塞后给予20%甘露醇或氟碳乳剂（20%氟索DA）是否能有效抑制这种肿胀。结果发现，甘露醇和氟碳乳剂联合使用可以预防脑肿胀，但单独使用甘露醇或氟碳乳剂则不行。基于这些结果，我们发现甘露醇与氟碳乳剂联合给药对血管闭塞6小时后的脑梗死具有保护作用。
