Thunberg T, Ahlborg U G, Håkansson H, Krantz C, Monier M
Arch Toxicol. 1980 Oct;45(4):273-85. doi: 10.1007/BF00293808.
The effect of various dietary sources of vitamin A on liver storage of retinol has been investigated in Sprague-Dawley rats treated with single oral doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): 0,0.1,1.0, or 10 microgram.kg-1. Each dose group consisted of 3 subgroups, each comprising 10 rats which received a diet with normal, low or high retinol content. The animals were killed 4 weeks after TCDD administration. Analyses of retinol were performed by high pressure liquid chromatography and glucuronosyltransferase activities were determined spectrophotometrically. A dose-dependent decrease in hepatic storage of retinol was evident. The high retinol diet did not fully compensate for the reduction caused by the highest TCDD-dose. Glucuronosyltransferase activity increased directly in relation to the TCDD-dose but in inverse proportion to the retinol content of the diet.
在用单次口服剂量为0、0.1、1.0或10微克/千克的2,3,7,8-四氯二苯并对二恶英（TCDD）处理的斯普拉格-道利大鼠中，研究了各种维生素A膳食来源对肝脏视黄醇储存的影响。每个剂量组由3个亚组组成，每个亚组包含10只接受正常、低或高视黄醇含量饮食的大鼠。在给予TCDD 4周后处死动物。通过高压液相色谱法进行视黄醇分析，并通过分光光度法测定葡萄糖醛酸转移酶活性。视黄醇的肝脏储存呈现剂量依赖性下降。高视黄醇饮食不能完全补偿最高TCDD剂量所导致的减少。葡萄糖醛酸转移酶活性与TCDD剂量直接相关，但与饮食中的视黄醇含量成反比。
