Sahay J N, Ibrahim N B, Chatterjee S S, Nassar W Y, Lodge K V, Jones C W
Clin Allergy. 1980 Jul;10(4):451-7. doi: 10.1111/j.1365-2222.1980.tb02128.x.
Ten patients with allergic perennial rhinitis completed a 3-month course of reatment with flunisolide nasal spray. Biopsy of the nasal mucosa was carried out before the initiation of treatment and at the end of the treatment period. The flunisolilde was administered as a 0.025% solution twice daily at a total daily dose of 200 micrograms. No histological abnormalities which could have been attributed to the effects of the drug were found in the post-treatment biopsies. Comparison of the pre- and post-treatment histological features showed either that there had been no apparent changes or that there had been a reduction in the oedema and/or cellular infiltration which had been present initially. All except one patient improved clinically and in this case the pre-treatment nasal biopsy demonstrated features of atrophic rhinitis.
10名变应性常年性鼻炎患者完成了为期3个月的氟尼缩松鼻喷雾剂治疗疗程。在治疗开始前和治疗期结束时对鼻黏膜进行活检。氟尼缩松以0.025%的溶液每日两次给药，每日总剂量为200微克。治疗后的活检中未发现可归因于药物作用的组织学异常。治疗前后组织学特征的比较显示，要么没有明显变化，要么最初存在的水肿和/或细胞浸润有所减轻。除1名患者外，所有患者临床症状均有改善，该患者治疗前的鼻活检显示为萎缩性鼻炎特征。
