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[婴儿利什曼原虫尼科勒,1908年,本地东方疖的病原体。关于在东比利牛斯分离出的2株菌株的生化鉴定]

[Leishmania infantum Nicolle, 1908, the agent of the autochthonous oriental sore. Apropos of the biochemical identification of 2 strains isolated in the eastern Pyrenees].

作者信息

Rioux J A, Lanotte G, Maazoun R, Perello R, Pratlong F

出版信息

C R Seances Acad Sci D. 1980 Oct 27;291(8):701-3.

PMID:6780226
Abstract

Two strains of parasites isolated from cases of oriental sore in the Pyrénées-Orientales were identified by electrophoretic analysis of eight isoenzymes (PGM, PGI, G-6-PDH, 6-PGDH, IDH, MDH, ME and GOT). Both strains were identical with Leishmania infantum Nicolle, 1908, which normally causes visceral leishmaniasis. It is probable that, in the Mediterranean region, some cutaneous lesions observed within the area of visceral leishmaniasis are caused by this species rather than by Leishmania tropica (Wright, 1903) or Leishmania major (Yakimoff and Schokor, 1914) traditionally believed to be agents of cutaneous leishmaniasis in the Old World.

摘要

通过对八种同工酶(磷酸葡萄糖变位酶、磷酸葡萄糖异构酶、葡萄糖-6-磷酸脱氢酶、6-磷酸葡萄糖酸脱氢酶、异柠檬酸脱氢酶、苹果酸脱氢酶、苹果酸酶和谷草转氨酶)进行电泳分析,鉴定了从东比利牛斯东方疖病例中分离出的两株寄生虫。两株寄生虫均与1908年的婴儿利什曼原虫相同,该原虫通常引起内脏利什曼病。在地中海地区,在内脏利什曼病区域观察到的一些皮肤病变很可能是由该物种引起的,而不是传统上认为是旧世界皮肤利什曼病病原体的热带利什曼原虫(赖特,1903年)或硕大利什曼原虫(亚基莫夫和肖科尔,1914年)。

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