四氧嘧啶糖尿病兔的屈光变化。黄酮类化合物的控制作用I。
Refractive change in alloxan diabetic rabbits. Control by flavonoids I.
作者信息
Varma S D, El-Aguizy H K, Richards R D
出版信息
Acta Ophthalmol (Copenh). 1980 Oct;58(5):748-59. doi: 10.1111/j.1755-3768.1980.tb06688.x.
Abstract
The rabbit eye is hyperopic by approximately 4D. The induction of diabetes leads to a further enhancement in the degree of hyperopia. This enhancement is attenuated substantially by flavonoids as inhibitors of aldose reduction. The development of refractive changes in diabetic lens involves aldose reductase catalyzed polyol synthesis.
摘要
兔眼约有4D的远视。糖尿病的诱发会导致远视程度进一步增加。作为醛糖还原酶抑制剂的类黄酮可大幅减弱这种增加。糖尿病晶状体屈光变化的发展涉及醛糖还原酶催化的多元醇合成。
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