Anderson D M, Dykstra M A
Mycopathologia. 1984 Jun 30;86(3):169-77. doi: 10.1007/BF00441128.
Mice were vaccinated with formalin-killed Cryptococcus neoformans either intranasally, intravenously, or intraperitoneally. Resistance to lethal challenge and in vitro phagocytic activity of alveolar and peritoneal macrophages was studied. Increased resistance to lethal challenge was seen following vaccination by each of the three routes but increased phagocytic activity was seen only in alveolar macrophages from mice vaccinated intranasally.
用福尔马林灭活的新型隐球菌分别通过鼻内、静脉内或腹腔内途径对小鼠进行接种。研究了小鼠对致死性攻击的抵抗力以及肺泡和腹腔巨噬细胞的体外吞噬活性。三种途径中的每一种接种疫苗后，小鼠对致死性攻击的抵抗力均增强，但仅在经鼻内接种疫苗的小鼠的肺泡巨噬细胞中观察到吞噬活性增强。
