Santiago T V, Sinha A K, Edelman N H
Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):382-7. doi: 10.1164/arrd.1981.123.4.382.
We studied ventilation, arterial blood gas tensions, and the ventilatory and airway occlusion pressure responses to hypercapnia of eight cats during wakefulness, quiet (slow-wave) sleep, and active (rapid-eye-movement) sleep. Responses to hypercapnia were measured before and during added airway resistance. Ventilation decreased, and arterial PCO2 increased during both slow-wave and rapid-eye-movement sleep. Unloaded ventilatory and airway occlusion pressure responses to hypercapnia decreased during slow-wave and rapid-eye-movement sleep as well. Flow-resistive loading caused awake cats to increase their occlusion pressure response to hypercapnia, thereby preserving their ventilatory responses. In contrast, during both slow-wave and rapid-eye-movement sleep, cats showed no augmentation of the occlusion pressure response and concomitant decrease of the ventilatory response to hypercapnia with the load. Thus, sleep was associated with loss of flow-resistive load compensation. It is postulated that, in an appropriate setting, this phenomenon could serve a protective function by decreasing the chances for progression from partial to complete upper airway obstruction during sleep.
我们研究了8只猫在清醒、安静（慢波）睡眠和活跃（快速眼动）睡眠期间的通气、动脉血气张力以及对高碳酸血症的通气和气道阻塞压力反应。在增加气道阻力之前和期间测量对高碳酸血症的反应。在慢波睡眠和快速眼动睡眠期间，通气量下降，动脉PCO2升高。在慢波睡眠和快速眼动睡眠期间，对高碳酸血症的无负荷通气和气道阻塞压力反应也下降。流阻负荷使清醒的猫增加其对高碳酸血症的阻塞压力反应，从而保持其通气反应。相比之下，在慢波睡眠和快速眼动睡眠期间，猫对高碳酸血症的阻塞压力反应没有增强，且随着负荷通气反应随之降低。因此，睡眠与流阻负荷补偿的丧失有关。据推测，在适当的情况下，这种现象可能通过减少睡眠期间从部分上气道阻塞发展为完全上气道阻塞的机会而起到保护作用。
Zotero 插件