Fry L, Haffenden G, Wojnarowska F, Thompson B R, Seah P P
Br J Dermatol. 1978 Jul;99(1):31-7. doi: 10.1111/j.1365-2133.1978.tb01957.x.
IgA deposits in the skin in 53 patients with dermatitis herpetiformis (DH) have been studied in relation to treatment. In 19 patients the disorder was controlled by a gluten-freen diet (GFD) alone, in 13 patients by dapsone and GFD and in 18 by dapsone alone. In 3 patients the skin disorder became insignificant and required no treatment. Of the patients taking a GFD alone, six had been clear of skin lesions for 7 years, 5 for 3--5 years, and 8 for periods of 6 months--3 years. IgA deposits were found in all patients in an initial biopsy in a second biopsy after treatment for periods varying from 1 to 7 years. There was no difference in the quantity of IgA, as assessed by the amount of fluorescence, whether patients were controlled with a GFD alone, GFD and dapsone, dapsone alone, or in those in clinical remission. The C3 component of complement was present in the skin in 3 of the 19 patients (16%) controlled by a GFD alone, 6 of the 13 patients (46%) of those controlled by a GFD and dapsone, and in 12 of 18 (66%) of the patients taking dapsone alone, and in one of the patients in clinical remission.
对53例疱疹样皮炎（DH）患者皮肤中的IgA沉积物与治疗的关系进行了研究。19例患者仅通过无麸质饮食（GFD）控制病情，13例患者通过氨苯砜和GFD控制病情，18例患者仅通过氨苯砜控制病情。3例患者的皮肤病变变得不明显，无需治疗。在仅采用GFD治疗的患者中，6例患者皮肤病变已清除7年，5例患者已清除3 - 5年，8例患者已清除6个月至3年。在治疗1至7年不等的时间段后，所有患者在初次活检及二次活检中均发现有IgA沉积物。通过荧光量评估，无论患者是仅用GFD、GFD和氨苯砜、仅用氨苯砜控制病情，还是处于临床缓解状态，IgA的量均无差异。在仅通过GFD控制病情的19例患者中有3例（16%）皮肤中存在补体C3成分，在通过GFD和氨苯砜控制病情的13例患者中有6例（46%）、仅服用氨苯砜的18例患者中有12例（66%）皮肤中存在补体C3成分，在临床缓解的患者中有1例皮肤中存在补体C3成分。
