Fry L, Leonard J N, Swain F, Tucker W F, Haffenden G, Ring N, McMinn R M
Br J Dermatol. 1982 Dec;107(6):631-40. doi: 10.1111/j.1365-2133.1982.tb00520.x.
Seventy-eight patients with dermatitis herpetiformis have been followed up for periods ranging from 3 to 14 years (mean 7.4). Forty-two patients were treated with gluten-free diet (GFD) and thirty-six took a normal diet (ND). Thirty of the forty-two (71%) taking the GFD were able to discontinue drugs previously needed to control their rash compared with five (14%) of the thirty-six patients taking a ND. The mean time taken to reduce drug requirements for patients taking a GFD was 8 months (range 4-30), and for stopping drugs, 29 months (range 6-108). The incidence of macroscopic abnormality of the small intestine decreased from 69 to 15%, and the mean intra-epithelial lymphocyte count decreased significantly in those patients taking a GFD, whereas there was no significant change in patients taking a ND. The improvement in the skin and intestinal lesions was related to the strictness of the GFD.
78例疱疹样皮炎患者接受了为期3至14年（平均7.4年）的随访。42例患者采用无麸质饮食（GFD），36例患者采用正常饮食（ND）。采用GFD的42例患者中有30例（71%）能够停用之前用于控制皮疹的药物，而采用ND的36例患者中只有5例（14%）能够停用。采用GFD的患者减少药物用量的平均时间为8个月（范围4 - 30个月），停用药物的平均时间为29个月（范围6 - 108个月）。采用GFD的患者小肠宏观异常的发生率从69%降至15%，上皮内淋巴细胞平均计数显著下降，而采用ND的患者则无显著变化。皮肤和肠道病变的改善与GFD的严格程度有关。
