Heading R C, Paterson W D, McClelland D B, Barnetson R S, Murray M S
Br J Dermatol. 1976 May;94(5):509-14. doi: 10.1111/j.1365-2133.1976.tb05138.x.
Patients with dermatitis herpetiformis have been studied prospectively for 2 years to assess the effect of a gluten-free diet (GFD) on control of the skin lesions. Daily requirements for oral medication with sulphapyridine or dapsone were reduced by GFD treatment and if complete clinical remission of the skin disease occurred, it was maintained while the diet was strictly observed. However, complete remission did not occur significantly more often in GFD-treated patients than in patients taking a normal diet. Many of the latter group exhibited variation in their drug dose requirements during the period of study. GFD treatment seems desirable for the majority of patients with dermatitis herpetiformis, not only to correct the intestinal abnormality but also to minimize the dose of drugs necessary to control the skin lesions.
对疱疹样皮炎患者进行了为期2年的前瞻性研究，以评估无麸质饮食（GFD）对控制皮肤损害的效果。GFD治疗可减少口服柳氮磺胺吡啶或氨苯砜的每日用药量，若皮肤病实现完全临床缓解，在严格遵守饮食规定的情况下可维持缓解状态。然而，接受GFD治疗的患者实现完全缓解的情况并不比食用正常饮食的患者更常见。后一组中的许多患者在研究期间其药物剂量需求存在变化。对于大多数疱疹样皮炎患者而言，GFD治疗似乎是可取的，这不仅是为了纠正肠道异常，也是为了尽量减少控制皮肤损害所需的药物剂量。
