Piepenbrock S, Zenz M, Sybrecht G W, Otten B
Anaesthesist. 1981 May;30(5):32-3.
In nine healthy young patients ventilatory CO2-response curves and mouth-occlusion pressure were measured after peridural injection of 5 mg morphine hydrochloride diluted in 10 ml saline solution in the lumbar region. Patients were not premedicated. Prior to measurements lower extremity operations were performed under peridural anaesthesia. Five minutes after peridural morphine injection there was a slight reduction in ventilatory response to increasing CO2 (94.7% +!- 15%), which was even more pronounced one hour later (74.5% +/- 14.7%). Mouth occlusion pressure decreased to 86.7% +/- 27.4% after 5 min to 72.4% +/- 13.4% after 60 min. Changes in the relation of the central stimulus P100 to the resulting flow (VT/Ti) was 96.7% +/- 32.5% after 5 min and 95.0% +/- 31.4% after 60 min. These results demonstrate a central respiratory depression after peridural morphine injection with a consequent reduction in ventilatory CO2-response.
在9名健康年轻患者中，于腰部硬膜外注射稀释在10毫升盐溶液中的5毫克盐酸吗啡后，测量了通气二氧化碳反应曲线和口腔闭合压。患者未进行术前用药。在测量前，下肢手术在硬膜外麻醉下进行。硬膜外注射吗啡5分钟后，对二氧化碳增加的通气反应略有降低（94.7%±15%），1小时后更为明显（74.5%±14.7%）。口腔闭合压在5分钟后降至86.7%±27.4%，60分钟后降至72.4%±13.4%。5分钟后中枢刺激P100与产生的流量（VT/Ti）的关系变化为96.7%±32.5%，60分钟后为95.0%±31.4%。这些结果表明硬膜外注射吗啡后出现中枢性呼吸抑制，随之通气二氧化碳反应降低。
