Bramble M G, Watson A J, Record C O
Digestion. 1981;21(6):316-24. doi: 10.1159/000198584.
The effect of the topical corticosteroid clobetasone butyrate on enzyme activity and morphology of duodenal mucosa was studied in 9 patients with coeliac disease and 10 controls using organ culture techniques. There was significant increase in mucosal alkaline phosphatase, lactase and maltase activities, but inclusion of a soluble extract of gluten reduced this effect. When clobetasone butyrate was also included in the culture medium significant elevations in enzymes were again observed. Enterocyte height was not affected by incorporation of gluten into the medium. Intra-epithelial lymphocyte counts fell significantly during the culture period. This improvement was also inhibited by gluten and overcome by addition of steroid.
采用器官培养技术，对9例乳糜泻患者和10例对照者研究了外用皮质类固醇丁酸氯倍他松对十二指肠黏膜酶活性和形态的影响。黏膜碱性磷酸酶、乳糖酶和麦芽糖酶活性显著增加，但加入麸质的可溶性提取物会降低这种作用。当培养基中也加入丁酸氯倍他松时，再次观察到酶活性显著升高。将麸质加入培养基中不影响肠上皮细胞高度。培养期间上皮内淋巴细胞计数显著下降。这种改善也受到麸质的抑制，并通过添加类固醇得以克服。
