在同种异体环境中，单克隆抗独特型抗体引发对磷酸胆碱的迟发型超敏反应。
Elicitation of delayed-type hypersensitivity to phosphorylcholine by monoclonal anti-idiotypic antibodies in an allogeneic environment.
作者信息
Arnold B, Wallich R, Hämmerling G J
出版信息
J Exp Med. 1982 Aug 1;156(2):670-4. doi: 10.1084/jem.156.2.670.
Abstract
Delayed-type hypersensitivity (DTH) to phosphorylcholine (PC) could be elicited by mixtures of monoclonal anti-idiotypic antibodies. Using this system in DTH transfers, the question was asked of whether anti-idiotypic antibodies could elicit antigen induced DTH in H-2-incompatible mice. Transfer of PC-activated BALB/c lymph node cells into BALB.K mice and subsequent elicitation with anti-idiotypic antibodies resulted in a positive DTH response. In contrast, elicitation with the antigen PC showed the expected H-2 restriction.
摘要
磷酸胆碱（PC）的迟发型超敏反应（DTH）可由单克隆抗独特型抗体混合物引发。在DTH转移实验中使用该系统，研究了抗独特型抗体是否能在H-2不相容的小鼠中引发抗原诱导的DTH。将PC激活的BALB/c淋巴结细胞转移到BALB.K小鼠中，随后用抗独特型抗体激发，结果产生了阳性DTH反应。相比之下，用抗原PC激发则显示出预期的H-2限制性。
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