Immunoglobulin genes undergo multiple sequence rearrangements during differentiation.

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作者信息

Rabbitts T H, Bentley D L, Dunnick W, Forster A, Matthyssens G E, Milstein C

出版信息

Cold Spring Harb Symp Quant Biol. 1981;45 Pt 2:867-78. doi: 10.1101/sqb.1981.045.01.104.

DOI:10.1101/sqb.1981.045.01.104

PMID:6790219

Abstract

摘要

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Immunoglobulin genes undergo multiple sequence rearrangements during differentiation.

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Fourteen nucleotides in the second complementarity-determining region of a human heavy-chain variable region gene are identical with a sequence in a human D minigene.人类重链可变区基因的第二个互补决定区中的14个核苷酸与人类D小基因中的一个序列相同。

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引用本文的文献

Immunoglobulin gene rearrangements in normal mouse B cells.正常小鼠B细胞中的免疫球蛋白基因重排

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Amino acid sequence of the Fv region of a human monoclonal IgM (protein WEA) with antibody activity against 3,4-pyruvylated galactose in Klebsiella polysaccharides K30 and K33.一种具有抗肺炎克雷伯菌多糖K30和K33中3,4-丙酮酸化半乳糖抗体活性的人单克隆IgM（蛋白WEA）Fv区的氨基酸序列。

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Three T cell hybridomas do not contain detectable heavy chain variable gene transcripts.三个T细胞杂交瘤不包含可检测到的重链可变基因转录本。

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Human immunoglobulin variable region genes: a new VH sequence used to detect polymorphism.人类免疫球蛋白可变区基因：用于检测多态性的一种新的VH序列。

Immunogenetics. 1987;25(3):184-92. doi: 10.1007/BF00344033.

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