Yesavage J A, Holman C A, Cohn R
Psychopharmacology (Berl). 1981;74(2):170-2. doi: 10.1007/BF00432687.
Two experiments are reported in which acute single test dose levels of thiothixene (Navane) were correlated with age. In the first study 20 mg oral doses were given to 28 male subjects and serum levels were drawn 2 h later. Mean age was 30 and correlation of serum level with age was 0.43, P less than 0.02. In a second older group with a mean age of 41, 10 mg oral doses were given to 25 subjects. A correlation with age of 0.41, P less than 0.05 was obtained with age. In prior work such acute levels have been found to correlate with steady-state serum levels and with clinical response to the medication. Few side-effects were seen in these populations and no correlations were obtained between serum levels and any side-effects.
本文报告了两项实验，其中硫代噻吨（Navane）单次急性测试剂量水平与年龄相关。在第一项研究中，给28名男性受试者口服20毫克剂量，2小时后采集血清水平。平均年龄为30岁，血清水平与年龄的相关性为0.43，P值小于0.02。在第二项平均年龄为41岁的老年组中，给25名受试者口服10毫克剂量。与年龄的相关性为0.41，P值小于0.05。在之前的研究中，已发现此类急性水平与稳态血清水平以及药物的临床反应相关。在这些人群中几乎未观察到副作用，血清水平与任何副作用之间均未发现相关性。
