Cupera Z
Vet Med (Praha). 1975 Apr;20(4):207-14.
The effectiveness of cerebrospinal avianized and tissue vaccines against rabies produced in Czechoslovakia was compared with that of some foreign vaccines. At the same time, the results obtained were compared with the international standard - vaccine obtained on request from the World Health Organization. The following methods were used for the determination of effectiveness: determination of the content of virus in vaccine in mice, effectiveness test in guinea-pigs -- Koprowski, effectiveness test and ED50 determination in mice -- our modification of Nazarov's method. The effectiveness of the Czechoslovak cerebrospinal vaccine was very good. The results were the same as in the case of the foreign vaccines (Soviet, Bulgarian) and the international standard vaccine used for comparison. The ED50 determined in these vaccines ranged from 2.49 mg to 8.0%. The avianized Czechoslovak vaccine showed higher effectiveness of foreign vaccines (Holland, Spain, Algeria). The immunogeneity index was 0.87--1.14. For the time being, tissue vaccines are produced in testing series in Czechoslovakia; nevertheless, they gave the same results as foreign vaccines (Soviet, French). The ED50 of tissue vaccines was found to range from 5.21 mg to 16.50 mg.
将捷克斯洛伐克生产的脑脊髓鸡胚化疫苗和组织疫苗对狂犬病的有效性与一些国外疫苗进行了比较。同时，将所得结果与国际标准——应世界卫生组织要求获得的疫苗进行了比较。采用以下方法测定有效性：小鼠体内疫苗病毒含量的测定、豚鼠有效性试验——科普罗夫斯基法、小鼠有效性试验及半数有效剂量（ED50）的测定——我们对纳扎罗夫方法的改进。捷克斯洛伐克脑脊髓疫苗的有效性非常好。结果与国外疫苗（苏联、保加利亚）以及用于比较的国际标准疫苗相同。这些疫苗中测定的ED50范围为2.49毫克至8.0%。捷克斯洛伐克鸡胚化疫苗显示出比国外疫苗（荷兰、西班牙、阿尔及利亚）更高的有效性。免疫原性指数为0.87至1.14。目前，捷克斯洛伐克正在生产试验系列的组织疫苗；然而，它们给出的结果与国外疫苗（苏联、法国）相同。发现组织疫苗的ED50范围为5.21毫克至16.50毫克。
