血清谷氨酸脱氢酶作为酒精性肝病中肝细胞坏死的标志物。
Serum glutamate dehydrogenase as a marker of hepatocyte necrosis in alcoholic liver disease.
作者信息
Mills P R, Spooner R J, Russell R I, Boyle P, MacSween R N
出版信息
Br Med J (Clin Res Ed). 1981 Sep 19;283(6294):754-5. doi: 10.1136/bmj.283.6294.754.
Abstract
Serum glutamate dehydrogenase concentration was assessed as a marker of the degree of hepatocyte necrosis found at liver biopsy in 95 patients suspected of having alcoholic liver disease. Although the serum concentration was raised in 54 patients, no relation between it and the severity of hepatocyte necrosis could be established. Glutamate dehydrogenase was therefore not confirmed to be a useful indicator of hepatocyte necrosis in patients with chronic alcoholism.
摘要
对95例疑似酒精性肝病患者进行肝活检，测定血清谷氨酸脱氢酶浓度，作为肝细胞坏死程度的指标。虽然54例患者的血清浓度升高，但未发现其与肝细胞坏死严重程度之间存在关联。因此，谷氨酸脱氢酶未被证实是慢性酒精中毒患者肝细胞坏死的有用指标。
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Clin Chem. 1972 Jun;18(6):523-7.
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Serum enzyme tests in diseases of the liver and biliary tree.
Am J Clin Pathol. 1978 Aug;70(2):248-58. doi: 10.1093/ajcp/70.2.248.
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Mitochondrial enzyme activities in liver biopsies from patients with alcoholic liver disease.酒精性肝病患者肝脏活检组织中的线粒体酶活性。
Gut. 1978 May;19(5):341-4. doi: 10.1136/gut.19.5.341.
4
Glutamate dehydrogenase: a reliable marker of liver cell necrosis in the alcoholic.谷氨酸脱氢酶：酒精性肝病中肝细胞坏死的可靠标志物。
Br Med J. 1977 Dec 10;2(6101):1508-10. doi: 10.1136/bmj.2.6101.1508.
5
Alcoholism and alcoholic liver injury: new diagnostic and prognostic tests.
Arch Pathol Lab Med. 1978 Aug;102(8):393-5.
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