福提霉素A与β-内酰胺类抗生素对铜绿假单胞菌的协同活性。

Synergistic activities of fortimicin A and beta-lactam antibiotics against Pseudomonas aeruginosa.

作者信息

Yamashita K, Kawabe H, Mitsuhashi S

出版信息

Antimicrob Agents Chemother. 1981 Jul;20(1):33-7. doi: 10.1128/AAC.20.1.33.

DOI:10.1128/AAC.20.1.33

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC181628/

Abstract

The inhibitory and bactericidal activities of fortimicin A (FTM-A) alone against Pseudomonas aeruginosa were compared with those of FTM-A in combination with beta-lactam antibiotics. As tested by the checkerboard method, most beta-lactam antibiotics tested had synergistic effects on the inhibitory activity of FTM-A against one strain of P. aeruginosa. Addition of a sublethal concentration of carbenicillin resulted in a significant increase in the rate of bacterial killing of FTM-A against P. aeruginosa. The antibacterial activity of FTM-A against 50 gentamicin-susceptible and 50 gentamicin-resistant clinical isolates of P. aeruginosa was clearly enhanced by addition of a subinhibitory concentration of carbenicillin or piperacillin.

摘要

将福提霉素A（FTM-A）单独对铜绿假单胞菌的抑制和杀菌活性与FTM-A与β-内酰胺类抗生素联合使用时的活性进行了比较。通过棋盘法测试，大多数受试β-内酰胺类抗生素对FTM-A对一株铜绿假单胞菌的抑制活性具有协同作用。添加亚致死浓度的羧苄青霉素导致FTM-A对铜绿假单胞菌的细菌杀灭率显著提高。添加亚抑菌浓度的羧苄青霉素或哌拉西林可明显增强FTM-A对50株对庆大霉素敏感和50株对庆大霉素耐药的铜绿假单胞菌临床分离株的抗菌活性。

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J Biol Chem. 1954 Jun;208(2):477-88.

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In vitro effects of carbenicillin combined with gentamicin or polymyxin B against Pseudomonas aeruginosa.羧苄青霉素联合庆大霉素或多粘菌素B对铜绿假单胞菌的体外作用

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