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福提霉素A与β-内酰胺类抗生素对铜绿假单胞菌的协同活性。

Synergistic activities of fortimicin A and beta-lactam antibiotics against Pseudomonas aeruginosa.

作者信息

Yamashita K, Kawabe H, Mitsuhashi S

出版信息

Antimicrob Agents Chemother. 1981 Jul;20(1):33-7. doi: 10.1128/AAC.20.1.33.

DOI:10.1128/AAC.20.1.33
PMID:6792980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC181628/
Abstract

The inhibitory and bactericidal activities of fortimicin A (FTM-A) alone against Pseudomonas aeruginosa were compared with those of FTM-A in combination with beta-lactam antibiotics. As tested by the checkerboard method, most beta-lactam antibiotics tested had synergistic effects on the inhibitory activity of FTM-A against one strain of P. aeruginosa. Addition of a sublethal concentration of carbenicillin resulted in a significant increase in the rate of bacterial killing of FTM-A against P. aeruginosa. The antibacterial activity of FTM-A against 50 gentamicin-susceptible and 50 gentamicin-resistant clinical isolates of P. aeruginosa was clearly enhanced by addition of a subinhibitory concentration of carbenicillin or piperacillin.

摘要

将福提霉素A（FTM-A）单独对铜绿假单胞菌的抑制和杀菌活性与FTM-A与β-内酰胺类抗生素联合使用时的活性进行了比较。通过棋盘法测试，大多数受试β-内酰胺类抗生素对FTM-A对一株铜绿假单胞菌的抑制活性具有协同作用。添加亚致死浓度的羧苄青霉素导致FTM-A对铜绿假单胞菌的细菌杀灭率显著提高。添加亚抑菌浓度的羧苄青霉素或哌拉西林可明显增强FTM-A对50株对庆大霉素敏感和50株对庆大霉素耐药的铜绿假单胞菌临床分离株的抗菌活性。

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本文引用的文献

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J Biol Chem. 1954 Jun;208(2):477-88.
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In vitro and in vivo antibacterial activity of KW1070, a new aminoglycoside antibiotic.新型氨基糖苷类抗生素KW1070的体外和体内抗菌活性
Antimicrob Agents Chemother. 1980 Feb;17(2):138-43. doi: 10.1128/AAC.17.2.138.
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In vitro effects of carbenicillin combined with gentamicin or polymyxin B against Pseudomonas aeruginosa.羧苄青霉素联合庆大霉素或多粘菌素B对铜绿假单胞菌的体外作用
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Bacteriological studies on the combined action of aminoglycoside antibiotics and synthetic penicillins against Pseudomonas aeruginosa.氨基糖苷类抗生素与合成青霉素联合作用对铜绿假单胞菌的细菌学研究
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Comparative activity of tobramycin, amikacin, and gentamicin alone and with carbenicillin against Pseudomonas aeruginosa.妥布霉素、阿米卡星和庆大霉素单独及与羧苄西林联合使用对铜绿假单胞菌的比较活性
Antimicrob Agents Chemother. 1974 Oct;6(4):442-6. doi: 10.1128/AAC.6.4.442.
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